Cymek said:

I wonder if humanity could create a pandemic to wipe most of us out.
Something engineered, fiction would have us believe its not too hard if you have the resources.

Such things exist. Some have existed for a long time, without human intervention.

Consider anthrax, consider plague (which is still around), consider ebola.

It’s not the existence of such biologicals that’s the problem, it’s only a question of effectively distributing them so as to outpace and overwhelm efforts to combat them.

Do that, and alles ist kaputt.